Grape seed extract has a wide variety of health benefits because it is a good source of a potent and natural antioxidant. Grape seed extract owes its free radical scavenging ability from a class of polyphenol referred to as proanthocyanidin, and studies demonstrate that proanthocyanidin has greater bioavailability compared to other antioxidants such as vitamins C, E and β-Carotene. Free radicals contribute to the formation of a spectrum of human disorders including arthritis, advanced ageing, injury to organs such as the liver, Alzheimer and Parkinson’s disease, gastrointenstinal dysfunctions, and cancer to name a few. The highly bioavailable antioxidants in grape seed extract makes it a potent defense against free radicals and related degenerative diseases such as liver and brain disorders[Bagchi et al. 2000].    

Reference(s) 

Bagchi, D., Bagchi, M., Stohs, S.J., Das, D.K., Ray, S.D., Kuszynski, C.A., Joshi, S.S., Pruess, H.G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148(2-3):187-97. 

Additional Readings

Bagchi, D., Bagchi, M., Stohs, S.J., Ray, S.D., Sen, C.K., and Preuss, H.G. (2002). Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci. 957:260-70.

Kong, X., Guan, J., Gong, S., and Wang, R. (2017).  Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury.  Chin Med Sci J. 32(2):92-9. doi: 10.24920/J1001-9294.2017.020.