Grape seed extract has a wide variety of health benefits because it is a good source of a potent and natural antioxidant. Grape seed extract owes its free radical scavenging ability from a class of polyphenol referred to as proanthocyanidin, and studies demonstrate that proanthocyanidin has greater bioavailability compared to other antioxidants such as vitamins C, E and β-Carotene. Free radicals contribute to the formation of a spectrum of human disorders including arthritis, advanced ageing, injury to organs such as the liver, Alzheimer and Parkinson’s disease, gastrointenstinal dysfunctions, and cancer to name a few. The highly bioavailable antioxidants in grape seed extract makes it a potent defense against free radicals and related degenerative diseases such as liver and brain disorders[Bagchi et al. 2000].