Probiotics are beneficial live bacteria that when ingested have beneficial effects on the preexisting microbiome in the body. The colony of microorganisms in the body is essential in maintaining physiological processes, most notably the conversion of food to essential nutrients and transport of nutrients in the body. It aids in the synthesis of Vitamin K which plays a role in hemostasis (e.g., coagulation of blood and repair on damaged blood vessels) .
It also protects the gut from harmful pathogens by colonizing the mucus layer of the gastrointestinal tract in a process referred to as colonization resistance, thus boosting gut immune system [ 11].
Probiotics also have anti-inflammatory and antioxidant capabilities that address various diseases throughout the body .
Live bacteria are most numerous in the gastrointestinal tract. In fact, there exist approximately trillions of bacteria belonging to 1,000 different species and composing of 5,000 strains in our digestive system .
Imbalanced or impaired microbiota (i.e., dysbiosis) links to various digestive diseases and disorders including Crohn's disease, ulcerative colitis, irritable bowel syndrome (IBS), and Clostridium difficile colitis .
Dysbiosis is also linked to metabolic syndrome (e.g., hypercholesterolemia, hypertension, obesity and type-2 diabetes 
, and psychiatric disorders including depression [ 8]
. Although research needs to expand to identify the specific function of particular strains, probiotics are collectively known to help with essential functions in the body [ 8].
Different species of microorganisms form a microecology within our body that is essential in holistic wellness. PureNature PROBIO50 contains 50 billion probiotics (beneficial live bacteria) to enhance your gut microbiome. The strains of bacteria in our formula belong to two of the most studied genera of microorganisms (Lactobacillus
spp. and Bifidobacterium
spp.) because of their role in food fermentation and probiotic property .
“Probiotic Lactobacillus species have been implicated in a variety of beneficial roles for the human body, including maintenance of the normal intestinal microbiota, pathogen interference, exclusion and antagonism, immunostimulation and immunomodulation, anticarcinogenic and antimutagenic activities, deconjugation of bile acids, and lactase release in vivo” [9
Clinical data demonstrate the probiotic effect of the species Lactobacillus acidophilus
and Bifidobacterium lactic
: 81]. The species Lactobacillus plantarum
is acknowledged for its utility in sugar transport and gene encoding in the body 
. Lactobacillus paracasei
is also a known probiotic bacteria typically used in yogurt, a product with acknowledged health benefits 
PureBIO50 contains the following strains of above-mentioned species of probiotics:
• Lactobacillus acidophilus (L-14)
• Bifidobacterium lactis (BI-04)
• Lactobacillus plantarum (Lp-115)
• Lactobacillus paracasei (LpC-37)